Aging and Health among Older Adults with Traumatic Brain Injury 

 
   Lead Investigator:    Kristen Dams-O'Connor
   Institution      :    Mount Sinai School of Medicine
   E-Mail           :    kristen.dams-o'connor@mountsinai.org
   Proposal ID      :    212


   Publications:


1  Dams-O'Connor K, Spielman L, Hammond FM, Sayed N, Culver C, Diaz-Arrastia R
   An exploration of clinical dementia phenotypes among individuals with and without traumatic brain injury
   Journal Article  NeuroRehabilitation,32:199-209,2013,PMC3767178

   PUBLISHED





   Proposal Description:
   The proposed pilot study will use existing data from the NACC dataset to evaluate whether individuals with a history of traumatic brain injury (TBI) demonstrate a pattern of cognitive decline (as measured by annual assessments of neuropsychological functioning) that is discernible from that seen among individuals with no history of TBI. The following questions will be addressed:                                                                                    1)  Can latent clinical phenotypes of neurocognitive functioning be identified and characterized among older adults in the NACC database, and does TBI history predict group/phenotype membership?                                                 2)  Does TBI history account for heterogeneity in cognitive decline over time?       3)  We will also evaluate whether TBI history of varying severity is associated  with earlier onset of dementia using cox proportional hazard models or appropriate extensions.